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KMID : 0614720090520101030
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Journal of Korean Medical Association
2009 Volume.52 No. 10 p.1030 ~ p.1036
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Incretin-based Combination Therapy in Type 2 Diabetes Mellitus
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Kim Jae-Hyeon
Lee Myung-Shik
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Abstract
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While there are many therapies for type 2 diabetes are available including insulin secretagogues, insulin sensitizers and exogenous insulin, many patients are unable to reach recommended therapeutic targets. Incretin-based therapies have recently been introduced into clinical practice, and these novel therapies may make it possible to achieve improved
glycemic control either with no weight gain (dipeptidyl peptidase-4 [DPP-4] inhibitors sitagliptin and vildagliptin, or with weight loss (glucagon-like peptide-1 [GLP-1] mimetics exenatide and liraglutide). This article aims to provide an overview of efficacy and safety data regarding incretinbased clinical trials in type 2 diabetic patients, and propose a systematic approach to treatment including patient selection and optimal treatment combination. In addition, preclinical data suggest that incretin-based therapies may also preserve-cell function. Therefore, these agents hold out promise of a truly disease-modifying therapy that would target the progressive nature of type 2 diabetes. Additional clinical trials will be required to test such hypothesis.
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KEYWORD
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DPP- 4 inhibitors, GLP -1 mimetics, Incretin, Type 2 diabetes
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